Who Treats This. Thereafter, scoliosis and vertebral maformations, including butterfly vertebrae and vertebral coronal cleft, have been added to the list. The distinction between the two syndromes is important because the diagnostic and treatment implications are significant. Neonatal hypocalcemia is recognized in most of children with Del Genet Couns.
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Current research demonstrates a unique profile of speech and language impairments is associated with 22q Pay a Bill. Phenotype of the 22q Affected individuals may also have breathing problems, kidney abnormalities, low levels of calcium in the blood which can result in seizures , a decrease in blood platelets thrombocytopenia , significant feeding difficulties, gastrointestinal problems, and hearing loss. Newer methods of analysis include Multiplex ligation-dependent probe amplification assay MLPA and quantitative polymerase chain reaction qPCR , both of which can detect atypical deletions in 22q Therefore, there is a marked variability in clinical expression between the different patients.
Velocardiofacial Syndrome (VCFS) / 22q11 Deletion Syndrome
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Deletion 22q Characteristic facial features include angular facies; small, posteriorly rotated ears with abnormal pinnae; and palatal abnormalities, such as a cleft of palate and submucosal cleft palate Figure 1, Figure 2, Figure 3, Figure 4. Velopharyngeal incompetence may be the only clinical presentation. Learning difficulties occur in more than 90 percent of affected individuals. The original designation, DiGeorge syndrome, characterized individuals with developmental impairment, congenital heart disease, craniofacial and palatal abnormalities, immunodeficiency, and hypocalcemia.
22q11.2 Deletion Syndrome
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Velocardiofacial Syndrome
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Clinical manifestations of Deletion 22q11.2 syndrome (DiGeorge/Velo-Cardio-Facial syndrome)
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